Chlordane (CAS 57-74-9, 12789-03-6) is a chlorinated cyclodiene manufactured for insecticidal use. To remove chlordane from indoor air requires either ventilation (Heat Exchange Ventilation) or activated carbon filtration. As you may read in the article, chlordane is a complex mixture. Agency for Toxic Substances & Disease Registry (ATSDR). increased levels of α-chlordane residues in dust (p. trend = 0.04), and a marginally significant trend was noted for increased levels of γ-chlordane (p. trend = 0.06). It is a white solid. Chemical remediation of chlordane in soils was attempted by the US Army Corps of Engineers by mixing chlordane with aqueous lime and persulfate. It is also neurotoxic and a skin and eye irritant. Indoor air in the … best use of that chlordane is to mix it and spray the hell out of your foundation line around the house with it. Although chlordane was routinely used outside the home up through March of 1988, it was often used for the indoor control of roaches and ants up until 1981. Health effects are more commonly seen in individuals that swallowed the compound. You can determine if your home was treated with chlordane by examining your records or contacting your termite treatment service. Oxychlordane is a metabolic by product of the pesticide chlordane. b. Crawl-Space Houses: Dig trench as above and apply emulsion at rate of 2 gallons per 5 lineal feet. Do not eat, drink or smoke when using this product. [13] Chlordane is excreted slowly through feces, urine elimination, and through breast milk in nursing mothers. Chlordane appears as a white or off-white crystals when synthesized, but it was more commonly sold in various formulations as oil solutions, emulsions, sprays, dusts, and powders. Prevention Obtain special instructions before use. [18], Exposure to chlordane/heptachlor and/or its metabolites (oxychlordane, heptachlor epoxide) are risk factors for type-2 diabetes,[19] for lymphoma,[20] for prostate cancer,[21] for obesity,[22] for testicular cancer,[23] for breast cancer. �(�w��b~�����\�'E��V��o QW Toxic Substances Portal: Chlordane. half in trench and half in back fill. Because of concern for harm to human health and to the environment, the United States Environmental Protection Agency (EPA) banned all uses of chlordane in 1983, except termite control in wooden structures (e.g. It is a white solid. chlordane, trans-chlordane, oxychlordane, and trans-nonachlor) detected in human liver samples were 17-fold higher when expressed on a fat rather than a wet-weight basis (Mussalo-Rauhamaa, 1991). chlordane emulsion per lineal foot in bottom of trench and 1/2 gallon per lineal foot in back fill. Chlordane is harmful to many different insects. ǀgșJP]����[ɋ�]&�O�$煿]"O�4�vH��%��G�RjUZ����[�;�l��]{�\�{�Ӏu�ҶUl-�.k*|�>��9}�>�{��?瘮+싾2�ڰ��U;��v},��i��a$�>���Y�ƠzK�����$N6�(�!�?@t`���&8M�pJ@�?�02�Ź�\�3)Һ�(��K>���:�Ԏ-�? Chlordane was easily purchased by homeowners from department stores before this date as an effective roach and ant pesticide. This ban of Chlordane took place because of a concern for damage to the environment and the potential of Chlordane to cause cancer. It was often mixed with emulsifiers to create a milky mixture and applied to the soil around infested homes. Getting the chemical into the soil could be a labor-intensive process. The star of the show stood right in the middle – a bottle of Chlordane. Based upon an estimated vapor pressure of 6.9X10-6 mm Hg at 25 °C, oxychlordane is expected to exist in both the vapor phase and particulate phase in the ambient … [17] It is highly toxic to fish, with an LD50 of 0.022–0.095 mg/kg (oral). The use of chlordane has been increasingly restricted in many countries (FAO, 1985; ATSDR, 1989; Worthing, 1991). Hexachlorocyclopentadiene forms a Diels-Alder adduct with cyclopentadiene to give chlordene intermediate [3734-48-3]; chlorination of this adduct gives predominantly two chlordane isomers, α and β, in addition to other products such as trans-nonachlor and heptachlor. Indoor areas routinely treated with chlordane include underneath the kitchen sink, behind the refrigerator, behind the … By 1998, all uses and sale were banned in the United States, the European Union, and many countries worldwide. After many reports of chlordane in the indoor air of treated homes, EPA banned the remaining use of chlordane in 1988. noun see chlordane * * * chlorˈdan or chlorˈdane / dan or dān/ noun A highly poisonous liquid insecticide • • • Main Entry: ↑chlor Wear protective … 1.5 Environmental fate Chlordane is very resistant to chemical and biological degradation. #D�Q � #{� https://pests.guru/termites/control/treatment/remedies/chlordane.html Chlordane, or chlordan, is an organochlorine compound used as a pesticide. Tests of the air in the residence of U.S. government housing, 32 years after chlordane treatment, showed levels of chlordane and heptachlor 10-15 times the Minimal Risk Levels (20 nanograms/cubic meter of air) published by the Centers for Disease Control. 1,3,4,7,8,9,10,10-Oc tachlorotricyclo[5.2.1.0~2,6~]dec-8-ene. Current OSHA PEL: 0.5 mg/m 3 TWA [skin] 1989 OSHA PEL: Same as current PEL 1993-1994 ACGIH TLV: 0.5 mg/m 3 TWA [skin] Description of Substance: Amber-colored, viscous liquid with a pungent, chlorine-like odor. x��&R�E�4j%5�Z0LO߅�P�j�|�Y�� �8"���. Chlordane (General Fact Sheet) Please refer to the Technical Fact Sheet for more technical information. The acute oral LD50 to 4-5 month old mallard ducklings was 1200 mg/kg body weight. This probability of developing cancer increases to 10 in 1,000,000 persons with an exposure of 100 ng/m3 and 100 in 1,000,000 with an exposure of 1000 ng/m3. The chlorine atoms, 7 in the case of heptachlor and 8 in chlordane, and 9 in the case of nonachlor, surround and stabilize the cyclodiene ring and thus these compounds are referred to as cyclodienes. By 1998, all uses and sale were banned in the United States, the European Union, and many countries worldwide. Though homeowners legally may still use chlordane, Dave Dunbar, an agent with the Lehigh County Extension Service, is taking a cautious approach. 22 0 obj <> endobj However chlordane is still available for human exposure because it is a very stable chemical and is anticipated to persist in the environment for some time. Chlordane was designated as a persistent organic pollutant in 1997 by the Governing Council of the United Nations Environment Programme (UNEP, 1997). Like other chlorinated cyclodiene insecticides, chlordane is classified as an organic pollutant hazardous for human health. ��jAW��2��8�q2��Q�>��T����,cD�K�?qN0��o녒�+1t� }�JD�V�}d. Chlordane.svg 593 × 415; 20 KB. CHLORDANE. [31], 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane, Chlordan; Chlordano; Ortho; Octachloro-4,7-methanohydroindane, Except where otherwise noted, data are given for materials in their, The examples and perspective in this article, Origin, pathways of exposure, and processes of excretion, Toxicological Profile for Chlordane, U.S. Department Of Health and Human Services, Agency for Toxic Substances and Disease Registry. The LC50 for bobwhite qualified chlordane in their diet for 10 weeks was 10 mg/kg diet. [14] A breakdown product of chlordane, the metabolite oxychlordane, accumulates in blood and adipose tissue with age.[15]. [5] The mixture that is composed of 147 components is called technical chlordane. Structure Chlordane.svg 152 × 124; 39 KB. [8] trans-Nonachlor is more toxic than technical chlordane and cis-nonachlor is less toxic. Oxychlordane (C10H4Cl8O), the primary metabolite of chlordane, and heptachlor epoxide, the primary metabolite of heptachlor, along with the two other main components of the chlordane mixture, cis-nonachlor and trans-nonachlor, are the main bioaccumulating constituents. Chlordane has a low vapor pressure and volatilizes slowly into the air of home/building above. Depending on the type of insect, sometimes chlordane powder was mixed with varying … ToxFaqs: September, 1995. [24], An epidemiological study conducted by the National Cancer Institute reported that higher levels of chlordane in dust on the floors of homes were associated with higher rates of non-Hodgkin lymphoma in occupants. Available at URL: Center for Disease Control and Prevention (CDC). Chlordane was available to the general public. It has a low aqueous solubility, is quite volatile and is not normally expected to leach to groundwater. [28] The Agency for Toxic Substances and Disease Registry (ATSDR) has defined a concentration of chlordane compounds of 20 ng/m3 as the Minimal Risk Level (MRLs). Source: Health Dangers of Chlordane by Dr. Edward Group Chlordane is a man made chemical and popular pesticide that was offered in the United States from 1948-1988. [10] The EPA recommends that children should not drink water with more than 60 parts of chlordane per billion parts of drinking water (60 ppb) for longer than 1 day. Exposure to chlordane through the air is considered to be low on the toxicity scale. [8][9], cis-chlordane (also known as α-chlordane (CAS=5103-71-9)), trans-chlordane (also known as γ-chlordane and beta-chlordane (CAS=5103-74-2)). Initially marketed as a large-scale ant control method, chlordane was quickly recognized as an effective insecticide against termites, roaches and other insects. --Leyo 20:25, 21 August 2016 (UTC) Untitled. In 1978, because of concern over cancer risk, evidence of human exposure and danger to wildlife, EPA canceled its use on food crops and phased out its other above-ground uses. After a 48 year-old woman had her home treated for termites with chlordane, she developed symptoms of nausea, sore throat and chest discomfort. Cis-chlordane-3D-balls.png 2,000 × 1,827; 478 KB. Avoid release to the environment. �`hE� 5yx��D>��A?�aE&�����PP�VH��=�q�`w�%�1�@�b�{�x�g�����{�z�����O�q������ +���=!o;zI�#Y�� Available at URL: Agency for Toxic Substances & Disease Registry (ATSDR). $ Chlordane is a pesticide first registered in the United States in 1948 (1). (1,3) Before 1978, chlordane was also used as a pesticide on agricultural crops, lawns, and gardens and as a fumigating agent. h�bbd``b`Z$�A�@ �u���v V3��Dq[A�� b>��"d ��L�K�,Fb���� w� [29], Chlordane was applied under the home/building during treatment for termites and the half-life can be up to 30 years. houses). [citation needed] It has an environmental half-life of 10 to 20 years. 38 0 obj <>/Filter/FlateDecode/ID[<4DC9E65ADA4BDD4794250CA12801FD01>]/Index[22 27]/Info 21 0 R/Length 81/Prev 54554/Root 23 0 R/Size 49/Type/XRef/W[1 2 1]>>stream However, chlordane use extended from the lower New England States south and west to California. %%EOF Due to concerns about environmental damage and human health risks, the U.S. Environmental Protection Agency banned the use of chlordane in 1983, except for controlling termites. Cyclodiene derives its name from hexachlorocyclopentadiene, a precursor in its production. Hence, it cannot be depicted by a single structure. %PDF-1.6 %���� Chlordane causes hepatotoxicity, neurotoxicity, and developmental toxicity … Chlordane is a broad-spectrum insecticide used to control termites and pests on field crops. Blood tests found low levels of chlordane in the woman's blood. [6] Exposure to the compound has been linked to cancers, diabetes, and neurological disorders. These products were sold in the United States from 1948 to 1988. Chlordane is a thick liquid that cannot be dissolved in water. [30] The fungus Phanerochaete chrysosporium has been found to reduce concentrations of chlordane by 21% in water in 30 days and in solids in 60 days. Currently, EPA has defined a concentration of 24 nanogram per cubic meter of air (ng/M3) for chlordane compounds over a 20-year exposure period as the concentration that will increase the probability of cancer by 1 in 1,000,000 persons. [7] The β-isomer is popularly known as gamma and is more bioactive. The human liver appears to also be vulnerable to damage from exposure to chlordane. [12] The United States Environmental Protection Agency reported that over 30 million homes were treated with technical chlordane or technical chlordane with heptachlor. Wash thoroughly after handling. [citation needed], Chlordane is very persistent in the environment because it does not break down easily. InChI=1S/C10H6Cl8/c1 1-3-1-2-4(5(3)12)9(1 6)7(14)6(13)8(2,15)1 0(9,17)18/h2 … I opened the door and beheld a rogue's gallery of garden pesticides banned long ago. back when termite treatments came with a 30 year gurarantee this is what they used. Later in 1988, the EPA banned all uses of Chlordane. h��Yio��+�QB L�`���D#VQ�/�Ê\�P$A�������كTD9AbŞ���Wս�k�5�V�q)�荷��`b�&F���DŽ6d��-ὠ��|��0;~2�^]�+���.��a���:�>__]��ﳗ���a�}{t4�����Lw�������������n�8:���?o�o?./��� ��fs�i5��|���m��t�ܬ���q2�o��[l���|u�Yo>?ޮ.�w���O�ϯ?����nn.W��X�s|w��b^��NW��ً������׍)>��|�^^./�Ly�?��m�,�$��5�j��r�q}���_?��ϗ�tyug�q��^��|__�� �v�Y~\ '������,N�Ȉ���js�k���+����d��\�_]\��N7���4-��8�rܮo6׷�O�x)�*�/�V������wX���kz���d����������?���������6N9��aC�0�Ȝ߲8���yIC�?�����+� :�8��v�*�q An unbroken barrier was required to keep … From 1983 to 1988, chlordane's only approved use was to control termites in homes. If trench is 30 inct,es deep. Other members of the cyclodiene family of organochlorine insecticides are aldrin and its epoxide, dieldrin, as well as endrin, which is a stereoisomer of dieldrin. Chlordane is an insecticide that is not approved for use in the EU. Trans-nonachlor and oxychlordane in serum of mothers during gestation has been linked with behaviors associated with autism in offspring at age 4-5. But there it was inside a cabinet in my Dad's old workshop. Insecticide levels were measured in dust taken from used vacuum cleaner bags (682 cases and 513 controls). use of chlordane for termite treatment was banned. It requires many years to degrade. Like other chlorinated cyclodiene insecticides, chlordane is classified as an … Chlordane, or chlordan, is an organochlorine compound used as a pesticide. Synthese Chlordan.svg 512 × 214; 66 KB. It is able to cross the placenta and become absorbed by developing fetuses in pregnant women. 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